Year : 2009  |  Volume : 3  |  Issue : 1  |  Page : 25-28

Comparing oral gabapentin versus clonidine as premedication on early postoperative pain, nausea and vomiting following general anesthesia

Department of Anesthesiology, School of Medicine, Medical sciences/University of Tehran, Dr Shariati hospital.

Correspondence Address:
Sussan Soltani Mohammadi
M.D., Department of Anesthesiology, Dr Shariati Hospital

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-354X.51831

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Background. Prevention and treatment of postoperative pain and postoperative nausea and vomiting (PONV), continue to be a major challenge in the postoperative care. This study was designed to compare the effects of small dose of oral gabapentin versus clonidine as premedication on early postoperative pain and on PONV in patients undergoing elective abdominal surgery under general anesthesia. Methods. In a randomized placebo controlled study, 120 ASA I and II patients scheduled for elective abdominal surgery were randomly assigned to receive either 0.2mg oral clonidine (n=40) or 300mg gabapentin (n=40) or placebo (n=40) 1hr before surgery. They were anesthetized using the same technique. Demographic data, post operative visual analogue scale (VAS), PONV and total morphine consumption by PCA pump were recorded in the recovery room and during first 6 hr after surgery. Results. Two patients in gabapentin compared with 13 patients in clonidine group (p<0.05) and 29 patients in placebo group (p<0.05) had VAS >3 in recovery room. The mean morphine consumptions were 4.757.5, 1.955.51 and 1.561.5mg in placebo, clonidine and gabapentin group with significant differences (P<0.05). These measurements were 1815.8, 13.112.6 and 12.112.9 mg respectively during first 6 hr after surgery with significant differences (P<0.05). PONV was not statistically different between the study groups in the recovery room and during first 6 hr after the surgery. Conclusion. This study showed that oral premedication with 300mg gabapentin reduces postoperative pain and total morphine consumption but not PONV during recovery and in the first 6 hr after abdominal surgery.

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