Year : 2022  |  Volume : 16  |  Issue : 1  |  Page : 104-107

Amlodipine overdose complicated by non-cardiogenic pulmonary edema and diffuse alveolar hemorrhage: A case report

1 Department of Medicine, Division of Pulmonary and Critical Care, University of Wisconsin Hospitals and Clinics, Madison, WI, USA
2 Department of Anesthesiology, Division of Critical Care, University of Wisconsin Hospitals and Clinics, Madison, WI, USA

Correspondence Address:
Will R Bringgold
UW CSC, Department of Medicine, 600 Highland Ave, Madison, WI 53792
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sja.sja_388_21

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A young adult female presented with hypotension and depressed mental status after intentional overdose of Amlodipine. After intubation and institution of lung-protective mechanical ventilation, initial management focused on maintenance of a mean arterial blood pressure over 65 mmHg and included fluid resuscitation (eight liters of crystalloid), Insulin and dextrose, intravenous calcium and, finally, vasopressor support. Her course was complicated by hypoxia due to non-cardiogenic pulmonary edema requiring diuresis. She was extubated soon thereafter but developed severe hypoxia within 72 hours requiring re-intubation. A subsequent bronchoscopy demonstrated diffuse alveolar hemorrhage (DAH). This is the first report of DAH complicating amlodipine overdose.

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