Saudi Journal of Anaesthesia

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 12  |  Issue : 2  |  Page : 297--303

Dexmedetomidine in a surgically inserted catheter for transversus abdominis plane block in donor hepatectomy: A prospective randomized controlled study


Mohamed Adel Aboelela1, Al-Refaey Kandeel1, Usama Elsayed1, Mohamed Elmorshedi1, Waleed Elsarraf1, Eman Elsayed2, Ahmed Elgawalby3, Ahmed Mohamed Sultan3, Mohamed Abdel Wahab3, Amr Yassen1 
1 Department of Anesthesia and Intensive Care, Faculty of Medicine, Mansoura University, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt
3 Department of General Surgery, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Dr. Mohamed Adel Aboelela
Faculty of Medicine, Mansoura University, Mansoura
Egypt

Background: Transversus abdominis plane (TAP) block is a promising technique for analgesia after abdominal surgery. This prospective, randomized controlled trial assessed the effect of adding dexmedetomidine to bupivacaine in TAP block for donor hepatectomy. We hypothesized that this would improve postoperative morphine consumption and reduce analgesia related complication and inflammation. Methods: A total of 50 donor hepatectomy were enrolled in this study. Patients divided into two equal groups according to drugs used for TAP block. Group (B) received 20 ml of bupivacaine hydrochloride 0.25%, Group (BD) received 20 ml of bupivacaine hydrochloride 0.25% and 0.3 μg/kg dexmedetomidine, on both sides at the end of surgery and every 8 h for 48 h at right side only through inserted catheter. Primary outcome objective was morphine consumption at first 72 h. Secondary outcome objectives were morphine requirement, numbers of intake, time to first intake, pain score numerical analog scale (NAS), postoperative analgesia related complications, recovery of intestinal motility, and inflammatory markers. Results: Data were analyzed, rescue morphine analgesia was significantly lower in (BD) group compared with (B) groups as considering total morphine consumption (B 4 ± 1.9, BD 1.5 ± 0.5, P = 0.03), numbers of morphine intake (P = 0.04), morphine requirement (P = 0.03), and first time of analgesia intake (P = 0.04). NAS was significantly lower in group (BD) compared with group (B) group in the first 12 h (NAS 0 - P = 0.001, NAS 1 - P = 0.03). Adding dexmedetomidine improved gut motility, first oral intake without detectable anti-inflammatory effect. Conclusion: Adding dexmedetomidine to bupivacine in a surgically inserted catheter for TAP block in donor hepatectomy reduced morphine consumption without detectable anti-inflammatory effect.


How to cite this article:
Aboelela MA, Kandeel AR, Elsayed U, Elmorshedi M, Elsarraf W, Elsayed E, Elgawalby A, Sultan AM, Wahab MA, Yassen A. Dexmedetomidine in a surgically inserted catheter for transversus abdominis plane block in donor hepatectomy: A prospective randomized controlled study.Saudi J Anaesth 2018;12:297-303


How to cite this URL:
Aboelela MA, Kandeel AR, Elsayed U, Elmorshedi M, Elsarraf W, Elsayed E, Elgawalby A, Sultan AM, Wahab MA, Yassen A. Dexmedetomidine in a surgically inserted catheter for transversus abdominis plane block in donor hepatectomy: A prospective randomized controlled study. Saudi J Anaesth [serial online] 2018 [cited 2022 Dec 3 ];12:297-303
Available from: https://www.saudija.org/article.asp?issn=1658-354X;year=2018;volume=12;issue=2;spage=297;epage=303;aulast=Aboelela;type=0