Saudi Journal of Anaesthesia

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 15  |  Issue : 4  |  Page : 390--395

Does propofol mode of administration influence psychomotor recovery time after sedation for colonoscopy: A prospective randomized assessor-blinded trial


Philippe J Van der Linden1, Hans Verdoodt1, Etienne Métallo1, Chantal Plasman1, Jean-François Fils2, Denis Schmartz1 
1 Department of Anesthesiology, Centre Hospitalo-Universitaire (CHU) Brugmann, Université Libre de Bruxelles, Nivelles, Belgium
2 Ars Statistica, Nivelles, Belgium

Correspondence Address:
Philippe J Van der Linden
Department of Anaesthesiology, CHU Brugmann, 4 Place Van Gehuchten, B - 1020 Brussels
Belgium

Background: Propofol sedation has become increasingly popular for colonoscopy. Different modes of propofol administration have been described, but their influence on psychomotor recovery time remains largely unknown. This prospective randomized assessor-blinded study tested the hypothesis that target-controlled infusion system (TCI) combined with sedation depth monitoring should be associated with a more stable sedation than intermittent bolus application with clinical monitoring of sedation depth, resulting in a faster psychomotor skills recovery. Methods: One hundred sixty-four patients undergoing colonoscopy were randomized to receive propofol with the former (TCI group) or the latter (bolus group) mode of administration. Psychomotor skill recovery was assessed using the Choice Reaction Time (CRT) performed before and every ten minutes after waking up from propofol sedation. Clinical recovery was also assessed using the modified Post-anesthetic Discharge Scoring System (PADS). Results: Induction and wake up times were longer in the TCI group, where patients received more propofol than those in the bolus group. Evolution of CRT was similar in both groups. Twenty minutes after arrival in the post-anesthesia care unit, 35 (49%) of patients in the TCI group and 43 (54%) in the bolus group achieved CRT values equal or shorter than their baseline values. Interestingly, according to the PADS score, most of the patients were considered fit for discharge at that moment. Incidence of adverse event was not different between groups. Conclusion: In the conditions of our study characterized by short procedure duration, target-controlled infusion of propofol does not offer any benefit in terms of psychomotor skills recovery over intermittent bolus application.


How to cite this article:
Van der Linden PJ, Verdoodt H, Métallo E, Plasman C, Fils JF, Schmartz D. Does propofol mode of administration influence psychomotor recovery time after sedation for colonoscopy: A prospective randomized assessor-blinded trial.Saudi J Anaesth 2021;15:390-395


How to cite this URL:
Van der Linden PJ, Verdoodt H, Métallo E, Plasman C, Fils JF, Schmartz D. Does propofol mode of administration influence psychomotor recovery time after sedation for colonoscopy: A prospective randomized assessor-blinded trial. Saudi J Anaesth [serial online] 2021 [cited 2022 Aug 10 ];15:390-395
Available from: https://www.saudija.org/article.asp?issn=1658-354X;year=2021;volume=15;issue=4;spage=390;epage=395;aulast=Van;type=0